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Arthrosamid Injection

What Is the Best Way to Relieve Knee Pain?

12 min read
A woman in her 50s sitting on a sofa holding her knee, representing knee pain relief options for women including osteoarthritis treatment in London

Knee pain is one of the most common complaints seen in private practice. Whether yours came on slowly over years or suddenly after a fall, this guide explains what actually works — and what to try first.

Nearly one in five adults in the UK lives with knee pain. For some it is a dull background ache they have learned to ignore. For others it is sharp, unpredictable, and life-limiting. Getting up from a chair, walking the dog, climbing stairs — things that should require no thought become daily negotiations with discomfort.

The honest answer to “what is the best way to relieve knee pain?” is: it depends on why your knee hurts. A runner with iliotibial band syndrome needs a very different approach to a 62-year-old woman with osteoarthritis. That said, there is a sensible order in which to try things — and a number of evidence-based options that work well for most people.

This guide takes you through all of them, from the simplest home measures to advanced treatments available at a private London clinic.

Why Knees Are So Prone to Pain

The knee is the largest joint in the body. It connects the thigh bone (femur) to the shin bone (tibia) and bears much of your body weight with every step. A 70kg person places around 210kg of force through each knee joint when walking on level ground. That figure triples when descending stairs.

It is a remarkable piece of engineering — but it is not indestructible. The cartilage that cushions the joint has no blood supply of its own, which means it heals slowly when damaged. The ligaments and tendons that stabilise it are under constant load. And, unlike a hip joint, the knee relies heavily on muscle strength — particularly the quadriceps — to absorb impact and protect its surfaces.

When any part of this system fails — through age, injury, inflammation, or weakness — pain follows.

The Most Common Causes of Knee Pain

Before reaching for a painkiller or booking an injection, it is worth understanding what is actually driving the pain. The most common causes include:

  • Knee osteoarthritis — the most common cause in people over 50. Cartilage wears away over time, leading to pain, stiffness, and swelling.
  • Meniscal tears — damage to the cartilage pads inside the knee, often from a twist or sporting injury.
  • Patellofemoral pain syndrome — pain around or behind the kneecap, common in younger active people and women in particular.
  • Iliotibial band syndrome — pain on the outer side of the knee, typically in runners and cyclists.
  • Bursitis — inflammation of the small fluid-filled sacs that cushion the joint.
  • Ligament injuries — sprains or tears to the ACL, MCL, or other stabilising ligaments.
  • Rheumatoid arthritis — an autoimmune condition that attacks joint lining and affects women three times more commonly than men.

Where your pain sits — front, back, inner edge, outer edge — can help narrow the cause down. But only a proper clinical assessment can confirm it. Treating the wrong diagnosis wastes time and money, and can sometimes make things worse.

“Knee pain is not simply an inevitable part of getting older. For most people, there is something specific driving it — and something specific that helps.”

The Best Ways to Relieve Knee Pain: A Practical Ladder

Think of treatment as a ladder. You start at the bottom — the simplest, lowest-risk options — and work up only if you need to. Most people find meaningful relief somewhere in the middle. Very few need to reach the top.

1Rest, ice, and load management For acute knee pain, rest is the first step. Reduce aggravating activities. Apply an ice pack wrapped in a cloth for 15–20 minutes, 3–4 times a day. Never apply ice directly to skin. Elevate the leg when resting to reduce swelling.  
Self-managed at home
2Over-the-counter pain relief Paracetamol is NICE’s first-line recommendation for mild to moderate knee pain. For swelling and inflammation, topical diclofenac gel applied directly to the knee is often more effective than oral tablets with fewer side effects. Oral ibuprofen or naproxen can help but use with caution if you have stomach, heart, or kidney conditions.  
Self-managed at home
3Gentle, targeted movement Movement is one of the most effective treatments for most types of knee pain. Staying still weakens the muscles that protect the joint. Low-impact activities such as swimming, cycling, and walking on flat ground keep the joint mobile without overloading it. Reduce running and jumping until pain settles.  
Self-managed at home
4Physiotherapy Targeted exercises to strengthen the quadriceps, hamstrings, and hip muscles take load off the knee joint and provide meaningful, lasting relief. Research consistently shows that muscle strengthening reduces osteoarthritis pain comparably to surgery in many patients. Ask your GP for an NHS referral or access a private physiotherapist directly.  
GP or self-refer
5Weight management Losing just 10% of body weight significantly reduces knee osteoarthritis symptoms. Every kilogram lost removes roughly four kilograms of force from the knee with each step. Your GP can refer you to a weight management service if needed.  
Discuss with your GP
6Steroid (cortisone) injections For acute flare-ups with significant swelling, a corticosteroid injection can provide rapid relief within a few days, lasting weeks to months. Repeated injections over time can damage cartilage and the relief window shortens. If you need injections more than twice a year, discuss other options with a specialist.  
Private or NHS specialist
7Advanced regenerative treatments For patients with mild to moderate osteoarthritis whose pain persists despite physiotherapy and lifestyle changes, Arthrosamid Injection — a non-biodegradable hydrogel — integrates with the synovial tissue inside the knee and may provide sustained relief for up to 5 years from a single injection. Available privately at Dr SNA Clinic, London.  
Private specialist
8Knee replacement surgery The most effective treatment for advanced osteoarthritis that has not responded to other approaches. Carries real surgical risks and a 3–6 month recovery period. The right choice for the right patient at the right time. Exhausting non-surgical options first is both clinically sensible and aligned with what most patients want.  
Surgical referral required

What Is the Fastest Way to Relieve Knee Pain at Home?

If your knee is painful right now and you need to manage it today, the most effective short-term approach combines rest, ice, and the right over-the-counter medication. Here is what to do — and what to avoid.

What helps quicklyWhat to avoid
Rest the knee — stop the aggravating activityIce wrapped in cloth, 15–20 minutes, 3–4 times dailyParacetamol — 1g every 4–6 hours as neededDiclofenac gel applied directly to the kneeElevate the leg when sitting or lying downGentle movement as tolerated — sitting still makes it worseHeat in the first 48–72 hours if the knee is swollenHeavy exercise or impact activity during a flare-upLong periods of complete immobilityContinuing to push through pain that is worseningRelying on painkillers long-term without addressing the causeRepeated steroid injections without specialist review
A note on heat vs ice:  Ice is better for acute, swollen, inflamed knees — particularly in the first few days after an injury or flare. Heat is better for chronic, stiff pain with no active swelling — for example, the morning stiffness of osteoarthritis that has been present for months. If in doubt, ice first.

Why Women Are More Affected by Knee Pain

Women are significantly more likely to develop knee osteoarthritis than men — and tend to experience it more severely and at an earlier age. This is not simply bad luck. There are clear biological reasons behind it.

Oestrogen plays a protective role in maintaining cartilage. When oestrogen levels fall sharply at the menopause, cartilage loses some of that protection. This is why many women notice their knee pain beginning or worsening noticeably in their 50s. Women also have a wider pelvis than men, which creates a greater angle between hip and knee (the Q-angle), placing more stress on the inner knee with every step. Differences in quadriceps strength and ligament laxity compound the issue.

If you are a woman in your 50s or 60s noticing worsening knee pain, it is worth seeking a proper assessment rather than accepting it as an inevitable part of ageing. Effective treatment options exist at every stage.

Does Exercise Help or Hurt Knee Pain?

This is one of the questions patients ask most often. The answer, for the vast majority of people with chronic knee pain or osteoarthritis, is that exercise helps — but the type of exercise matters.

Strong quadriceps muscles at the front of the thigh are the knee’s primary shock absorbers. Weak quadriceps mean the joint itself absorbs more impact. Strengthening these muscles through targeted exercise — leg presses, wall squats, straight leg raises — is one of the most evidence-backed treatments for knee osteoarthritis available. Studies consistently show that people who follow a structured strengthening programme report as much pain relief as those who receive steroid injections, with benefits that last longer.

The key is choosing the right exercises. High-impact activities — running on hard surfaces, jumping, heavy squatting — can aggravate an already irritated joint. Low-impact strengthening, cycling, and hydrotherapy are far better starting points. A physiotherapist can design a programme tailored to your specific condition.

When Should You See a Doctor About Knee Pain?

Many episodes of knee pain settle with self-management within two to four weeks. But there are situations where seeing a doctor promptly is important.

See your GP if:  your knee pain has not improved after two to three weeks of self-management, the pain is severe enough to affect your daily routine or sleep, you notice significant swelling that is not settling, or the pain came on after a specific injury and you cannot bear weight comfortably.
Seek urgent medical attention if you experience: Severe pain after an injury, or a loud popping sound at the time of injuryInability to bear any weight on the affected legSignificant deformity around the knee jointA hot, red, extremely swollen knee — particularly with fever (may indicate joint infection or gout)Sudden, severe knee pain in someone on blood-thinning medication

Can Knee Pain Be Relieved Without Surgery?

For many patients, yes — including those with quite significant osteoarthritis. Surgery is the right answer for some people, particularly those with very advanced joint damage. But the majority of patients who come to Mr Abbas at Dr SNA Clinic are people who want to find an effective alternative to surgery.

The Arthrosamid injection is specifically designed to fill the gap between “physiotherapy and pain relief are no longer enough” and “I’m not ready for a knee replacement.” Clinical studies report sustained pain relief and improved function for up to five years after a single injection in suitable patients. For someone who has been managing knee osteoarthritis for years, that kind of relief — without surgery, without recovery time, without anaesthetic — is significant.

Not everyone is a candidate. Arthrosamid works best for mild to moderate osteoarthritis. Advanced bone-on-bone disease may require surgical assessment. The only way to know is a proper clinical evaluation by a specialist who will give you an honest answer either way.

Frequently Asked Questions

What is the fastest way to relieve knee pain?

For acute knee pain, the fastest short-term relief comes from rest, ice applied for 15–20 minutes several times a day, and paracetamol or topical diclofenac gel. For a sudden severe flare in someone with osteoarthritis, a corticosteroid injection can reduce pain significantly within two to three days. For longer-lasting relief, Arthrosamid injection improves gradually over eight to twelve weeks and may provide benefit for several years.

What is the best painkiller for knee pain?

NICE recommends paracetamol as the first-line choice for mild to moderate knee pain. Topical diclofenac gel is often the next step, particularly for osteoarthritis. Oral ibuprofen or naproxen can help with inflammation but should be used with caution in older patients or those with stomach, heart, or kidney problems. No painkiller addresses the underlying cause.

My knee hurts when I bend it and straighten it. What does that mean?

Pain or stiffness on bending and straightening — particularly first thing in the morning or after sitting for a while — is one of the most common early signs of knee osteoarthritis. A clinical assessment and imaging review are needed to confirm the cause.

Can I exercise with knee pain?

In most cases, yes — and it is usually recommended. Low-impact exercise such as swimming, cycling, and walking strengthens the muscles that protect the knee. High-impact activities should be reduced during a flare. A physiotherapist can guide you safely for your specific condition.

How long does knee pain usually last?

Acute knee pain from a minor injury typically settles within two to four weeks with appropriate self-management. Chronic knee pain from osteoarthritis does not resolve on its own but fluctuates between periods of calm and flare. Effective management reduces both frequency and severity of symptoms considerably.

Is Arthrosamid available on the NHS?

No. Arthrosamid is not currently available on the NHS. NICE has not yet included it in standard NHS commissioning pathways for knee osteoarthritis. It is available privately. Some private health insurers do cover it. 0% finance is available at Dr SNA Clinic to help spread the cost.

Is Your Knee Pain Limiting Daily Life? Mr S N Abbas sees patients from across the UK and internationally at 48 Wimpole Street, London. Consultations are thorough, honest, and free of obligation. If Arthrosamid is not right for you, he will tell you — and guide you to what is. Book a consultation from £100  —  drsnaclinic.com/arthrosamid-injection

This article is intended for general information only and does not constitute medical advice. Always consult a qualified healthcare professional before starting any new treatment. Medically reviewed by Mr S N Abbas, MBBS, MRCSEd, MSc (Distinction), Consultant Orthopaedic Specialist, Dr SNA Clinic, 48 Wimpole Street, London W1G 8SF. Updated March 2026.