If you’re looking for a way to rejuvenate your skin without fillers, blood draws, or long downtime, Polynucleotide (PN) injections may be the treatment you’ve been waiting for. This innovative regenerative skin therapy harnesses purified DNA fragments to stimulate your skin’s natural healing and collagen-building processes. The result? Smoother, firmer, and more hydrated skin that looks refreshed and youthful.

In this article, we’ll explain what PN injections are, how they work, their benefits, and why they’re becoming one of the fastest-growing treatments in modern aesthetics.

What Are Polynucleotides for Skin?

Polynucleotides (PN) are purified fragments of DNA, usually derived from salmon or trout, that act as biostimulatorswhen injected into the skin. Once inside the dermis, they “wake up” fibroblasts—the cells responsible for producing collagen and elastin—and encourage them to regenerate.

Because these DNA fragments closely resemble human DNA, they integrate seamlessly without triggering immune reactions. In simple terms, they repair, hydrate, and protect the skin at a cellular level.

How Do PN Injections Work?

Unlike fillers that add immediate volume or lasers that create controlled injury, PN injections regenerate skin from the inside out. Their effects unfold gradually over several weeks as new collagen and elastin fibers are rebuilt.

The treatment works through three main mechanisms:

• Cellular Repair – PN fragments encourage DNA repair and cell regeneration, helping restore skin structure and strength.
• Deep Hydration – Their molecular structure attracts and binds water, boosting moisture and giving the skin a healthy plumpness.
• Anti-Inflammation – They calm irritation and redness, making PN especially helpful for sensitive or acne-prone skin.

Together, these processes deliver firmer, more radiant skin with long-lasting improvements in quality and resilience.

PN Injections vs PRP and Fillers

Many patients ask how PN compares to other popular skin treatments.

• PRP (Platelet-Rich Plasma): PRP uses your own blood platelets to stimulate collagen growth. While effective, results can vary depending on individual blood chemistry. PN, on the other hand, uses purified DNA manufactured to pharmaceutical standards, offering more consistent and predictable outcomes.
• Dermal Fillers: Hyaluronic acid fillers plump lines and restore lost volume instantly. PN doesn’t add volume—it works gradually to rebuild skin health. This means results look subtle and natural, without the “overfilled” effect.
• Lasers and Peels: These treatments resurface skin by causing micro-injuries or exfoliation. PN avoids damage entirely, regenerating skin gently from within, with minimal downtime.

In short, fillers change shape, PRP depends on blood quality, and PN restores skin quality itself.

Benefits of Polynucleotide Skin Therapy

The appeal of PN injections lies in their ability to address multiple signs of aging at once. Patients typically notice improvements in hydration and glow soon after treatment, with deeper collagen and elastin changes developing over weeks.

Key benefits include:

• Softer fine lines and wrinkles as collagen remodels
• Firmer, tighter, and more elastic skin
• Smoother texture and more even tone
• Deep, long-lasting hydration for plumpness and radiance
• Reduced redness, irritation, and post-acne scarring
• Fading of dark spots and under-eye pigmentation
• Faster healing and skin repair after injury or damage

Recent clinical studies (2024–2025) confirm these effects, showing consistent improvements in wrinkle depth, elasticity, and overall skin quality.

Treatment Process, Safety, and Recovery

One of the biggest advantages of PN therapy is its safety profile. The DNA fragments are thoroughly purified, making allergic reactions extremely rare.

• The Procedure: Treatment begins with skin cleansing and a numbing cream. A fine needle or cannula is then used to inject PN into targeted areas such as the face, under-eyes, neck, or hands.
• Comfort and Downtime: Most patients report minimal discomfort. Afterward, mild redness or swelling may occur but usually resolves within 24–48 hours. Makeup can typically be worn the next day.
• Sessions Required: For optimal results, most people need three to four sessions spaced two to four weeks apart. Maintenance treatments every four to six months help sustain results.
• Side Effects: Aside from mild bruising or redness, side effects are rare and temporary.

This makes PN injections an excellent choice for those wanting visible rejuvenation without the downtime of more aggressive procedures.

Why Are PN Injections Becoming So Popular?

Polynucleotide therapy has quickly gained global recognition and even earned the nickname “salmon DNA facial.”Celebrities, beauty influencers, and dermatologists are all talking about it—and for good reason.

The rise in popularity comes from a combination of factors:

• Patients want natural, subtle results rather than dramatic changes.
• The science behind PN feels cutting-edge and futuristic.
• Early adopters share impressive before-and-after results.
• PN works across multiple skin types and concerns.
• Short recovery time fits into busy lifestyles.

In today’s aesthetics market, where “wellness and natural beauty” trends dominate, PN therapy is perfectly aligned with patient demand.

Book Your PN Consultation at Dr SNA Clinic

If you’re ready to experience the benefits of polynucleotide skin therapy, the team at Dr SNA Clinic can help. Our specialists in regenerative aesthetics will assess your skin, explain how PN injections work for your needs, and design a treatment plan tailored to your goals.

• Restore hydration, elasticity, and glow—naturally.
• Achieve subtle, youthful results without downtime.
• Feel confident with a cutting-edge, science-backed therapy.

📞 Contact Dr SNA Clinic today to book your consultation and start your journey to healthier, more radiant skin.

FAQ About Polynucleotide (PN) Skin Treatments

1)Are polynucleotide injections safe?

Yes. PN injections use purified DNA fragments that are biocompatible and safe for all skin types. Side effects are minimal and usually limited to temporary redness or swelling.

2)How many PN sessions do I need?

Most patients need three to four sessions spaced two to four weeks apart. Maintenance treatments every few months help prolong results.

3)How are PN different from fillers?

Fillers add volume immediately, while PN gradually regenerate the skin’s structure by stimulating collagen and elastin production.

4)When will I see results from PN injections?

Hydration and glow often improve within days, while firmer skin and wrinkle reduction develop over several weeks.